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机体免疫状态与肿瘤发生发展关系多年来为人们重视。50年代初,用纯种小鼠移植肿瘤实验初次证明化学致癌物及病毒诱发的肿瘤具有肿瘤特异性移植抗原以来,陆续发现许多化学致癌物或致癌病毒诱发动物肿瘤及动物自发瘤皆有肿瘤相关抗原。许多肿瘤患者的临床表现,以及一些体内外肿瘤免疫试验提示人类肿瘤亦具有肿瘤相关抗原及针对此抗原之免疫反应。
The relationship between the immune status of the body and the development of tumors has drawn people’s attention for many years. In the early 1950s, with pure mice transplanted tumor experiments for the first time that chemical carcinogens and virus-induced tumors with tumor-specific transplant antigen, one after another found that many chemical carcinogens or oncogenic virus-induced animal tumors and animal tumors are tumor-related antigen. The clinical manifestations of many tumor patients, as well as some tumor immunoassays in vitro and in vivo, suggest that human tumors also have tumor-associated antigens and immune responses against this antigen.