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雄激素和性激素结合球蛋白可预测中年男性的代谢综合征和糖尿病一项群组研究对低水平睾酮和性激素结合球蛋白(SHBG)与男性代谢综合征和糖尿病发展的关系进行了评价。该研究入选702名既无糖尿病也无代谢综合征的芬兰中年男性。随访11年发现,147名男性发展为代谢综合征,57名出现糖尿病。校正年龄后,总睾酮、计算游离睾酮和SHBG水平处于下1/4组者,发展为代谢综合征和糖尿病的危险增加数倍。研究者认为,中年男性的低水平睾酮和SHBG能独立预测代谢综合征和糖尿病的发生。因此,雄激素缺乏是胰岛素和葡萄糖代谢紊乱的早期标记,并可能在代谢综合征和糖尿病的发病机制中起一定作用(Diabetes Care,2004,27:1036-1041)。
Androgen and Sex Hormone-binding Globulin Predict Metabolic Syndrome and Diabetes in Middle-aged Men A cohort study evaluated the association of low-level testosterone and sex hormone-binding globulin (SHBG) with the development of metabolic syndrome and diabetes in men. The study enrolled 702 middle-aged Finnish men with neither diabetes nor metabolic syndrome. Eleven years of follow-up found that 147 men developed metabolic syndrome and 57 developed diabetes. After adjustment for age, total testosterone, calculated free testosterone and SHBG levels in the lower quartile, increased to a multiple of the risk of developing metabolic syndrome and diabetes. The researchers believe that low levels of testosterone and SHBG in middle-aged men independently predict the occurrence of metabolic syndrome and diabetes. Therefore, androgen deficiency is an early marker of disorders of insulin and glucose metabolism and may play a role in the pathogenesis of metabolic syndrome and diabetes (Diabetes Care, 2004, 27: 1036-1041).