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干细胞(stem cell)是一类具有自我复制能力的多潜能细胞,可分化为多种功能性成体细胞。其增殖及分化受多种信号通路的调控,如:Wnt/β-catenin、Sonic hedgehog、Notch等;其中Notch介导的细胞间信号转导在该过程中发挥重要作用[1-2]。Notch基因最早在果蝇体内发现,得名于其功能部分丢失能够导致果蝇翅缘出现一缺口(Notch)[3],是一组在进化上高度保守的信号转导系统[4]。
Stem cells are pluripotent cells that have the ability to self-replicate and differentiate into a variety of functional adult cells. Its proliferation and differentiation are regulated by a variety of signaling pathways, such as Wnt / β-catenin, Sonic hedgehog, Notch, etc .; Notch-mediated intercellular signal transduction plays an important role in this process [1-2]. The earliest Notch gene was found in Drosophila melanogaster, whose deletion of its functional part leads to a notch (Notch) in the wing margin of Drosophila melanogaster [3]. It is a group of evolutionarily conserved signal transduction systems [4].