应激是心血管疾病发生的机理之一,内质网应激是亚细胞器水平的应激。内质网内钙稳态失衡,错误折叠蛋白质聚集等都可引起内质网应激。研究发现内质网应激参与动脉粥样硬化的形成;同时还介导组织缺血再灌注时的细胞损伤和细胞死亡;预先诱发内质网应激可以通过改善再灌注损伤时细胞钙超载保护心肌细胞。 Stress is one of the mechanisms of cardiovascular disease. Endoplasmic reticulum stress is sub-organelle-level stress. Endoplasmic reticulum calcium imbalance, misfolded protein aggregation can cause endoplasmic reticulum stress. Endoplasmic reticulum stress is involved in the formation of atherosclerosis; at the same time, it also mediates cell injury and cell death during tissue ischemia-reperfusion; pre-induced endoplasmic reticulum stress can protect cells against calcium overload by reperfusion injury Cardiomyocytes.