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目的 :探讨正常妊娠及妊高征孕妇一氧化氮水平的变化及意义。方法 :测定正常未孕妇女、正常妊娠早、中、晚期妇女和妊高征患者血清一氧化氮的稳定代谢产物硝酸盐 /亚硝酸盐 (NO- 3 /NO- 2 )浓度 ,观察不同孕龄的正常孕妇和妊高征患者一氧化氮水平的变化。结果 :妊娠早期与未孕妇女血清 (NO-3 /NO-2 )水平无显著性差异 (t=0 335 ,P >0 0 5 ) ,妊娠早、中、晚期孕妇间有显著性差异 (F =3 347,P <0 0 5 ) ,妊娠中、晚期显著高于妊娠早期 (P均 <0 0 5 )。妊高征患者一氧化氮水平显著低于妊娠晚期孕妇 (t=3 6 0 7,P <0 0 0 1)。结论 :一氧化氮可能参与了妊娠期的适应性生理变化 ,并与妊高征的发病有关
Objective: To investigate the changes and significance of nitric oxide in normal pregnancy and pregnancy induced hypertension. Methods: The concentrations of nitric oxide / nitrite (NO-3 / NO-2), a stable metabolite of serum nitric oxide in normal pregnant women, normal pregnant women with early pregnancy, middle and late pregnancy, and patients with pregnancy induced hypertension were measured. Of normal pregnant women and pregnancy-induced hypertension patients with nitric oxide levels. Results: There was no significant difference in the serum levels of NO-3 / NO-2 between the first trimester and the second trimester (t = 0 335, P 0 05). There was a significant difference between the pregnant women in the early, middle and late stages of pregnancy = 3 347, P <0 05), which was significantly higher in the second and third trimester than in the third trimester (P <0.05). The level of nitric oxide in patients with PIH was significantly lower than that in the third trimester (t = 3600, P <0.01). Conclusion: Nitric oxide may be involved in the adaptive physiological changes during pregnancy and is associated with the pathogenesis of PIH