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目的 观察补肾益智方对去卵巢大鼠学习记忆的影响。方法 月龄约3个月SD雌性大鼠,随机分为假手术组、模型组、补肾益智方组、雌激素对照组,模型组行双侧卵巢切除术,补肾益智方组、雌激素对照组分别在卵巢切除术后予补肾益智方灌胃和结合雌激素皮下注射。运用Morris水迷宫测试各组大鼠参考记忆和工作记忆的变化。结果与结论 SD大鼠在卵巢切除16周后,雌激素水平明显降低,行为学也发生了相应的变化,表现为工作记忆的能力降低,而参考记忆则没有明显的变化。补肾益智方及结合雌激素对卵巢切除大鼠工作记忆能力的降低能够起到明显的保护作用。
Objective To observe the effect of Bushen Yizhi Recipe on learning and memory in ovariectomized rats. Methods SD female rats aged about 3 months were randomly divided into sham operation group, model group, Bushen Yizhi group and estrogen control group. Model group was performed bilateral ovariectomy, Bushen Yizhi group and estrogen. The control group received intragastric administration of the Bushen Yizhi Recipe and subcutaneous estrogen injection subcutaneously after ovariectomy. The Morris water maze was used to test the changes of reference memory and working memory in each group of rats. Results and Conclusions After 16 weeks of ovary resection, SD rats showed significantly lower levels of estrogen and a corresponding change in behavioral behavior. The performance of the SD rats was reduced by the ability to work memory, but there was no significant change in the reference memory. Bushen Yizhi Recipe combined with estrogen can significantly reduce the memory impairment of ovariectomized rats.