目的　评价国产封堵器治疗膜周部室间隔缺损 (VSD)疗效。方法　自 2 0 0 3年以来 ,采用膜部VSD封堵器对 5例膜周部VSD患者进行封堵治疗 ,经胸超声心动图 (TTE)提示VSD直径 4～ 10mm。所有患者在透视及超声监测下通过建立股动静脉轨道、经右心系统释放封堵器。并分别于术后 1个月、3个月、6个月进行超声、心电图、胸片随访评价。结果　 5例患者封堵器置入全部成功 ,术后无残余分流、溶血及其他严重并发症发生。随访中无封堵器移位、脱落以及瓣膜损伤等。结论　国产封堵器治疗膜周部VSD近、中期效果良好 ,我们将进一步观察远期疗效。 Objective To evaluate the efficacy of domestic occluder in the treatment of perimembranous ventricular septal defect (VSD). Methods From 2003, 5 cases of perimembranous VSD were treated with occluder of diaphragm VSD, and transthoracic echocardiography (TTE) showed VSD diameter of 4 ~ 10mm. All patients underwent fluoroscopy and ultrasound monitoring by establishing femoral venous orbitals and releasing occluders via the right heart system. And were 1 month after surgery, 3 months, 6 months ultrasound, electrocardiogram, chest X-ray follow-up evaluation. Results All the occluders were successfully inserted in 5 patients. No postoperative shunts, hemolysis and other serious complications occurred. No follow-up occluder displacement, loss and valve damage. Conclusion Domestic occluder VSD near the membrane, the medium-term effect is good, we will further observe the long-term efficacy.