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以纯种小鼠Ｃ（５７）骨髓细胞的姐妹染色单体互换（ＳＣＥ）和微核（ＭＮ）为指标，进行致变与抗变的双向研究。致变检测结果：胃安３号口服液３个剂量组的ＳＣＥ、ＭＮ频率均在正常范围，表明无致变效应，即在微观上无毒副作用。抗变检测结果：胃安３号口服液３个剂量组的ＳＣＥ、ＭＮ频率均明显低于实验（阳性）对照组（Ｐ＜０．０５）．表明有抗变效应，即在基因水平上起防治作用。
Using the sister chromatid exchange (SCE) and micronucleus (MN) markers of purebred mouse C (57) bone marrow cells as indicators, a bidirectional study of mutagenesis and anti-mutagenicity was performed. Mutagenesis test results: The frequency of SCE and MN in the 3 doses of Weian No. 3 Oral Solution was in the normal range, indicating that there was no mutagenic effect, ie no toxic side effects on the microscopic side. Anti-variant test results: The frequency of SCE and MN in three doses of Wei’an No. 3 Oral Liquid was significantly lower than that of the experimental (positive) control group (P<0.05). It shows that there is an anti-mutagenic effect, that is, it plays a preventive and therapeutic role at the gene level.