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目的:通过研究环氧合酶-2(COX-2)蛋白在胃癌组织中的表达,探讨其在胃癌发生、发展中的作用及与病理参数的关系。方法:应用免疫组织化学SP法检测12例正常胃组织及40例胃癌组织中COX-2的表达。结果:COX-2在胃癌组织中的表达(87.5%)明显高于正常胃组织(25.0%)(P<0.05);Ⅲ+Ⅳ期胃癌中COX-2的表达(96.55%)高于Ⅰ+Ⅱ期胃癌组织(63.64%)(P<0.05);淋巴结转移组COX-2的表达(96.43%)高于无淋巴结转移组(66.67%)(P<0.05)。结论:COX-2蛋白的阳性表达与胃癌TNM分期及淋巴结转移有关,COX-2的高表达可能参与了胃癌形成的过程,且与胃癌的侵袭、转移及预后有一定关系。
OBJECTIVE: To investigate the expression of cyclooxygenase-2 (COX-2) in gastric carcinoma and its relationship with the development and progression of gastric carcinoma. Methods: The expression of COX-2 in 12 cases of normal gastric tissue and 40 cases of gastric carcinoma was detected by immunohistochemical SP method. Results: The expression of COX-2 in gastric cancer tissues (87.5%) was significantly higher than that in normal gastric tissues (25.0%) (P <0.05) (63.64%) (P <0.05). The expression of COX-2 in lymph node metastasis group (96.43%) was higher than that in non-lymph node metastasis group (66.67%) (P <0.05). Conclusions: The positive expression of COX-2 protein is related to the TNM staging and lymph node metastasis of gastric cancer. The high expression of COX-2 may be involved in the process of gastric cancer formation, which may be related to the invasion, metastasis and prognosis of gastric cancer.