论文部分内容阅读
目的研究玉米赤霉烯酮对去卵巢大鼠子宫内膜细胞的增殖作用影响。方法将成年雌性大鼠去卵巢后,给予不同剂量的玉米赤霉烯酮(0.01mg/kg、0.05mg/kg和0.20mg/kg)连续3d,观察去卵巢大鼠子宫内膜细胞有丝分裂指数和嗜银染色颗粒数。结果玉米赤霉烯酮低、中、高3个剂量组有丝分裂指数和嗜银染色颗粒数,均高于阴性对照组,差异有显著性(P<0.05),且有明显的剂量-效应关系。结论玉米赤霉烯酮能加速去卵巢大鼠子宫内膜细胞的分裂和增殖,因此,推断它在大鼠体内可能具有雌激素样作用。
Objective To study the effect of zearalenone on the proliferation of endometrial cells in ovariectomized rats. METHODS: After ovariectomy of adult female rats, different doses of zearalenone (0.01 mg/kg, 0.05 mg/kg, and 0.20 mg/kg) were given consecutively for 3 days to observe the mitotic index of endometrial cells in ovariectomized rats. Aggressive silver stained particles. Results The zearalenone index and the number of silver-stained particles in the low, middle and high doses of zearalenone were higher than those in the negative control group. The difference was significant (P<0.05), and there was a significant dose-effect relationship. Conclusion Zearalenone can accelerate the division and proliferation of endometrial cells in ovariectomized rats. Therefore, it is inferred that it may have estrogen-like effects in rats.