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目的观察在急性病毒性肝炎重症倾向的早期使用糖皮质激素(地塞米松)的疗效及预防重型肝炎的作用。方法41例病人随机分成治疗组20例,对照组21例,两组病例均给予常规护肝、降酶、退黄等处理及对症支持治疗,治疗组给予地塞米松10mg静滴,每日1次,7～10天停药。结果治疗后10天、20天治疗组肝功能血清胆红素下降与对照组比较差异有显著性(P<0.01、0.05>P>0.01),治疗组重型肝炎发病数及病死数与对照组比较差异有显著性(0.05>P>0.01、0.05>P>0.01)。结论急性病毒性肝炎重症倾向的早期使用地塞米松可有效降低血清胆红素,降低重型肝炎的发病率及病死率。
Objective To observe the curative effect of early use of glucocorticoid (dexamethasone) and prevention of severe hepatitis in the severe tendency of acute viral hepatitis. Methods Forty-one patients were randomly divided into treatment group (n = 20) and control group (n = 21). Patients in both groups were treated with regular liver protection, enzyme-degrading and yellowing treatment and symptomatic supportive treatment. Times, 7 to 10 days withdrawal. Results The decrease of serum bilirubin in the treatment group on the 10th day and the 20th day after treatment was significantly different from that of the control group (P <0.01, 0.05> P> 0.01). The incidence and mortality of severe hepatitis in the treatment group were significantly lower than those in the control group The difference was significant (0.05> P> 0.01, 0.05> P> 0.01). Conclusion The early use of dexamethasone in acute severe hepatitis may reduce serum bilirubin and reduce the incidence and mortality of severe hepatitis.