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对102例慢性胆囊炎壁肥厚和12例慢性胆囊炎后性壁肥厚型腺癌，采用ras癌基因P21蛋白和细胞核DNA含量进行观察。结果发现P21蛋白在慢性胆囊炎壁肥厚中随异型增生程度增加而递增，重度的慢性胆囊炎壁肥厚与胆囊炎壁肥厚型腺癌相接近。细胞核DNA含量在慢性胆囊炎壁肥厚中相对倍体均值增高，重度的慢性胆囊炎壁肥厚与胆囊炎后性壁肥厚型腺癌无显著性差异（P＞0．05）。提示慢性胆囊炎壁肥厚腺上皮增生、异型，最后发展为胆囊炎后性壁肥厚型腺癌。
The ras oncogene P21 protein and nuclear DNA content were observed in 102 cases of chronic cholecystitis wall hypertrophy and 12 cases of chronic cholecystitis posterior wall hypertrophic adenocarcinoma. It was found that P21 protein increased with the degree of dysplasia in chronic cholecystitis wall hypertrophy, and severe chronic cholecystitis wall hypertrophy was similar to cholecystitis wall hypertrophic adenocarcinoma. The nuclear DNA content increased in the relative ploidy of chronic cholecystitis wall hypertrophy, and the severe chronic cholecystitis wall hypertrophy was not significantly different from post-cholecystitis hypertrophic adenocarcinoma (P>0.05). Tip chronic cholecystitis wall hypertrophy gland epithelial hyperplasia, heterogeneous, and finally developed after cholecystitis hypertrophic adenocarcinoma.