为研究经颅低强度钬激光切除大型垂体腺瘤的临床效果，１８例大型垂体腺瘤经颅用低强度钬激光切除，其中２例在显微镜下全切除。结果，本法切除大型垂体腺瘤，尤其配备显微镜，使病变与周围组织显示清晰，能在很小的术野下，随意操纵光纤切割、汽化病变组织。结果表明，钬激光用于颅内肿瘤切除，特别是在显微镜下更为安全有效。 In order to study the clinical effects of transcranial low-intensity holmium laser ablation of large pituitary adenomas, 18 cases of large pituitary adenomas were transcranially excised with a low-intensity holmium laser, and 2 of them were completely resected under a microscope. As a result, this method removes large pituitary adenomas, especially equipped with microscopes, so that the lesions and the surrounding tissues are clearly visible, and it is possible to arbitrarily manipulate optical fibers to cleave and vaporize diseased tissues in a small surgical field. The results showed that He-Ne laser is used for intracranial tumor resection, especially under the microscope is more safe and effective.