论文部分内容阅读
以预胶化淀粉为赋型剂，制备阿昔洛韦胶囊，其体外溶出（Ｔ８０＝１０．８８ｍｉｎ）明显快于市售片剂（Ｔ８０＝１５．５２ｍｉｎ）；其人体相对生物利用度的药－时曲线下面积ＡＵＣ＝３．７９７８±０．２６４０μｇ·ｈ／ｍｌ及峰浓度Ｃｍａｘ＝０．５８９±０．０２９μｇ／ｍｌ，显著高于市售片剂，其ＡＵＣ＝１．７７０８±０．１４１９μｇ·ｈ／ｍｌ；Ｃｍａｘ＝０．４８０±０．０２３μｇ／ｍ
The acyclovir capsules were prepared with pregelatinized starch as excipient, which was significantly faster than the commercial tablets (T80 = 15.52 min) in vitro (T80 = 10.88 min). The relative bioavailability of the drug - The area under the curve AUC = 3.7978 ± 0.2640 μg · h / ml and the peak concentration Cmax = 0.589 ± 0.029 μg / ml, significantly higher than the commercial tablets, with AUC = 1.7708 ± 0. 1419 μg · h / ml; Cmax = 0.480 ± 0.023 μg / m