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在探索男用避孕方法的过程中,用精子抗原作为一种免疫避孕疫苗的设想始终是十分吸引人的。精子对男性是一个自身抗原,对女性是一个同种异体抗原,从理论上来说,用精子抗原作为避孕疫苗是可行的。下表是几种雌性动物用同种精子加上免疫佐剂注射后对生育力及胚胎死亡率影响的观察结果。早在1932年就有用人精液给妇女注射作
The idea of using a sperm antigen as an immunization contraceptive vaccine has always been fascinating in the exploration of the male contraceptive method. Sperm is an autoantigen to men and an allogeneic to women. Theoretically, it is feasible to use sperm antigen as a contraceptive vaccine. The following table is several females with the same kind of sperm plus immune adjuvant injection on fertility and embryo mortality observed. As early as 1932, there was the use of semen for injection to women