论文部分内容阅读
目的探讨肿瘤坏死因子-α(TNF-α)和表皮生长因子(EGF)在经尿道体外冲击波碎石术(ESWL)的变化和规律。方法采用放射免疫分析法,选择性地对50例肾单发结石患者ESWL前后TNF-α和EGF含量进行测定。结果碎石后尿中TNF-α含量在1~4d与术前比较总体水平明显升高(t=2.22,P<0.05),术后2dTNF-α含量明显高于术后4d(t=2.82,P<0.01),第5天水平回落,与术前比较差异无统计学意义(P<0.05);EGF的含量术后明显高于术前(t=2.28,P<0.05)。结论TNF-α和EGF水平可能提示肾小管细胞的自身炎症过程及与肾损害的发生机制密切相关。
Objective To investigate the changes and regularities of tumor necrosis factor-α (TNF-α) and epidermal growth factor (EGF) in transurethral extracorporeal shock wave lithotripsy (ESWL). Methods Radioimmunoassay was used to determine the levels of TNF-α and EGF before and after ESWL in 50 patients with renal calculi. Results The level of TNF-α in the urine of the gravel after 1 ~ 4 days was significantly higher than that before operation (t = 2.22, P <0.05) (P <0.01). There was no significant difference between the first 5 days and the preoperative (P <0.05). The content of EGF was significantly higher than that before operation (t = 2.28, P <0.05). Conclusions The levels of TNF-α and EGF may indicate the renal tubular epithelial cells’ own inflammatory process and the pathogenesis of renal damage.