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选取2013年2月~2015年8月于我院就诊的孕妇2710例,孕周为9~14周,测定其糖化血红蛋白值,HbA_(1c)>6.0%为筛查结果阳性,根据结果分为阳性组和阴性组。24~28周时,对全部患者行葡萄糖耐量试验(OGTT),以确诊妊娠期糖耐量异常,并进行随访。结果:HbA_(1c)进行筛查的灵敏度为80.65%、特异性为97.98%、阳性预测值为33.34%、假阳性率为1.99%、假阴性率为0.22%。HbA_(1c)阳性组孕妇妊娠期糖代谢异常的发生率明显高于HbA_(1c)阴性组,差异有统计学意义(P<0.05)。结论:HbA_(1c)对早期的妊娠期糖代谢异常有较高的灵敏度、特异性、阳性预测值,且操作简单易行,可广泛用于临床的早期筛查,做到早发现、早治疗,降低母婴的并发症。
A total of 2710 pregnant women were enrolled in our hospital from February 2013 to August 2015. The gestational age ranged from 9 to 14 weeks. HbA 1c was found to be 6.0% positive for screening results. According to the results, Positive and negative groups. At 24 to 28 weeks, all patients underwent glucose tolerance test (OGTT) to confirm gestational abnormal glucose tolerance and follow-up. Results: The sensitivity of HbA 1c screening was 80.65%, the specificity was 97.98%, the positive predictive value was 33.34%, the false positive rate was 1.99% and the false negative rate was 0.22%. The incidence of abnormal glucose metabolism in pregnant women with HbA 1c positive group was significantly higher than that in HbA 1c negative group (P <0.05). Conclusion: HbA_ (1c) has high sensitivity, specificity and positive predictive value for the abnormal glucose metabolism in early gestational period, and it is simple and easy to operate. It can be widely used in early clinical screening and early detection and early treatment , Reduce maternal and child complications.