尿毒症如果存在神经系统异常,常限于四肢轻度感觉改变,主观上常无症状,病理改变是轴退变,继发性脱髓鞘,其特有的改变是所有纤维包括有髓和无髓纤维的神经传导速度(NCV)普遍减慢而最粗和较远端的纤维最易受损。有少数尿毒症病人可以发生严重的进行性的以运动障碍为主的神经病,而引起肌肉萎缩和无力。作者报告4例,均为晚期肾功能衰竭者。例一,男,15岁,肾功能衰竭患者,曾行间断腹膜透析、血液透析,后行两肾切除,血液透析期间反复发生金黄色葡萄球菌性菌血症,同时出现周围神经病,主要是运动障碍,下肢重于上肢,严重 Uremia if there is nervous system abnormalities, often limited to mild sensory changes in limbs, subjective often asymptomatic, pathological changes are axial degeneration, secondary demyelination, its unique change is that all fibers, including myelinated and non-myelinated fibers Of the nerve conduction velocity (NCV) generally slow down the coarsest and more distal fiber most vulnerable. A small number of uremic patients can occur serious progressive dyskinesia-based neuropathy, causing muscle atrophy and weakness. The authors report 4 cases, all patients with advanced renal failure. Example 1, male, 15 years old, patients with renal failure, had intermittent peritoneal dialysis, hemodialysis, two nephrectomy after hemorrhagic staphylococcus aureus bacteremia repeated during hemodialysis, while peripheral neuropathy, mainly exercise Obstacles, lower extremity heavier than the upper limbs, serious