Fas是细胞表面诱导凋亡的死亡受体,FasL(Fas Ligand,FasL)是Fas在机体内的天然配体,是死亡分子。Fas与Fas L结合,可向细胞传递死亡信号,引发细胞凋亡。肿瘤细胞通过Fas/FasL介导体内抗肿瘤T细胞凋亡,来反击体内免疫系统,并且通过抵抗Fas/FasL介导的凋亡成为免疫赦免部位而逃逸免疫系统攻击,得以生存和发展。本文拟就上述有关内容进行综述。 1 Fas 基因定位、结构和分布 1989年、日、美两个科研小组分别从小鼠分离出对人体 Fas is a death receptor that induces apoptosis on the cell surface. FasL (Fas Ligand, FasL) is a natural ligand for Fas in the body and is a death molecule. Fas and Fas L binding, the death signal can be transmitted to the cell, triggering apoptosis. Tumor cells counteract the immune system in vivo by mediating anti-tumor T cell apoptosis in vivo by Fas / FasL and survive and develop by counteracting Fas / FasL-mediated apoptosis as an immunopapillary site that escapes the immune system attack. This article intends to summarize the above content. 1 Fas gene localization, structure and distribution 1989, Japan, the United States two scientific groups were isolated from mice on the human body