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目的探讨小剂量低分子肝素钙在治疗慢性阻塞性肺病中的临床应用。方法选取新密市第一人民医院2011年1月至2013年1月收治的88例慢性阻塞性肺病患者,将其随机分为观察组44例和对照组44例。对照组患者给予抗感染、低流量吸氧、强心利尿、扩血管、化痰止咳平喘等常规治疗,观察组患者在此基础上给予小剂量低分子肝素钙治疗,比较两组患者临床治疗效果、血气分析结果及不良反应情况。结果观察组患者治疗总有效率为90.9%,对照组患者治疗总有效率为77.3%,两组比较差异有统计学意义(P<0.05);两组患者动脉血氧分压、动脉血二氧化碳分压均有明显改善,且观察组改善情况明显优于对照组(P<0.05);两组患者均未出现严重不良反应(P>0.05)。结论在常规治疗的基础上联合小剂量低分子肝素钙治疗慢性阻塞性肺病,有助于改善患者血气情况,安全有效,值得推广。
Objective To investigate the clinical application of low-dose low molecular weight heparin calcium in the treatment of chronic obstructive pulmonary disease. Methods 88 patients with chronic obstructive pulmonary disease admitted from Xinmi First People’s Hospital from January 2011 to January 2013 were randomly divided into observation group (44 cases) and control group (44 cases). Control group patients were given anti-infection, low flow oxygen, cardiac diuretic, vasodilator, Huatanzhike asthma and other conventional treatment, the observation group were given low-dose low molecular weight heparin on the basis of this treatment, the clinical treatment of two groups were compared Effect, blood gas analysis results and adverse reactions. Results The total effective rate was 90.9% in the observation group and 77.3% in the control group, with significant difference between the two groups (P <0.05). The arterial partial pressure of oxygen and arterial carbon dioxide Pressure were significantly improved, and the observation group improved significantly better than the control group (P <0.05); no serious adverse reactions in both groups (P> 0.05). Conclusion Combined with low-dose low-molecular-weight heparin calcium in the treatment of COPD on the basis of routine treatment, it is helpful to improve the blood gas condition of patients and is safe and effective.