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以放射免疫分析法测定了急性心肌梗塞（ＡＭＩ）大鼠血浆。垂体中β－内腓肽（β－ＥＰ）含量，并采用推挽灌流技术动态观察了延髓孤束核中β－ＥＰ浓度在ＡＭＩ后的动态过程。结果发现，ＡＭＩｈ时血浆、垂体β－ＥＰ含量明显高于对照组（血浆３２４８．９±８８９：１３９０．５±４８２ｐｇ／ｍｌ；垂体１０７±６７．５：４７．４±４３．８ｎｇ／ｍｇ），孤束核中β－ＥＰ含量在ＡＭＩ１～１．５ｈ时最高。提示：ＡＭＩ时有β－ＥＰ激活现象，且不同部位、不同时程的β－ＥＰ激活可能有不同的病理生理意义，值得进一步探讨。
Plasma of acute myocardial infarction (AMI) rats was determined by radioimmunoassay. Β-EP in the pituitary gland. The dynamic process of β-EP concentration in the medulla oblongata was observed by the push-pull perfusion technique after AMI. The results showed that the levels of β-EP in plasma and pituitary at AMIh were significantly higher than those in control group (plasma 3248.9 ± 889: 1390.5 ± 482pg / ml; pituitary 107 ± 67.5: 47.4 ± 43.8ng / mg) , The content of β-EP in nucleus tractus solitarius was the highest at AMI1 ~ 1.5h. It is suggested that there is β-EP activation phenomenon in AMI, and β-EP activation in different parts and time courses may have different pathophysiological significance, which deserves further exploration.