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目的:探讨硫普罗宁钠对抗结核药物性肝炎的治疗效果。方法:将120例抗结核药物性肝炎患者随机分成治疗组60例,治疗组给以硫普罗宁钠0.2g加入5%葡萄糖注射液250ml,静脉滴注,1次/d;对照组给以一般护肝药物作为对照。结果:治疗后两组患者的ALT、AST、TBL均有下降,且与治疗前相比有统计学差异(P<0.01),临床总有效率治疗组优于对照组(P<0.01)。结论:硫普罗宁钠治疗抗结核药物性肝炎效果明显。
Objective: To investigate the therapeutic effect of tiopronin on anti-TB drug-induced hepatitis. Methods: A total of 120 patients with anti-TB drug-induced hepatitis were randomly divided into treatment group (60 cases). The treatment group was treated with sulindac sodium 0.2g with 250ml 5% dextrose injection, intravenous drip once a day and control group Liver drug as a control. Results: After treatment, the ALT, AST and TBL in both groups decreased, with statistical significance (P <0.01). The total effective rate in the treatment group was better than that in the control group (P <0.01). Conclusion: The effect of tiopronin in treating anti-tuberculosis drug-induced hepatitis is obvious.