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目的 研究粘附分子 Ｅｃａｄｈｅｒｉｎ 在胆囊腺癌中的表达及与胆囊腺癌分化、侵袭、转移和预后的关系。方法 应用免疫组织化学方法对５７ 例原发性胆囊腺癌、３７ 例慢性胆囊炎石蜡包埋标本进行 Ｅｃａｄｈｅｒｉｎ 半定量检测。结果 分别有 ４５ 例（７８．９％ ）胆囊腺癌组织及 １１ 例（２９．７％ ）慢性胆囊炎组织中 Ｅｃａｄｈｅｒｉｎ 呈阴性或不同程度表达减弱。 Ｔ１、 Ｔ２ 期癌 Ｅｃａｄｈｅｒｉｎ 表达阳性率明显高于 Ｔ３、 Ｔ４ 期癌（ Ｐ＜ ０．０５）。 Ｅｃａｄｈｅｒｉｎ 表达阳性者其２ 年生存率（２７．３％ ）明显高于表达阴性者（８．３％ ），差异有显著性（ Ｐ＜ ０．０５）。结论 Ｅｃａｄｈｅｒｉｎ 表达与胆囊腺癌 Ｐ Ｔ Ｎ Ｍ 分期呈负相关，其表达水平可作为胆囊癌患者预后判断的生物学指标。
Objective To investigate the expression of adhesion molecule Ecadherin in gallbladder adenocarcinoma and its relationship with differentiation, invasion, metastasis and prognosis of gallbladder adenocarcinoma. Methods Immunohistochemistry was used to semi-quantitatively detect E-cadherin in paraffin-embedded specimens of 57 cases of primary gallbladder adenocarcinoma and 37 cases of chronic cholecystitis. Results 45 cases (78.9%) of gallbladder adenocarcinoma tissues and 11 cases (29.7%) of chronic cholecystitis were negative for E-cadherin or different degrees of expression. The positive rates of E-cadherin expression in T1 and T2 tumors were significantly higher than those in T3 and T4 tumors (P<0.05). The 2-year survival rate (27.3%) of patients positive for E-cadherin expression was significantly higher than that of negative expression (8.3%), with a significant difference (P<0.05). Conclusion The expression of Ecadherin is negatively correlated with P T N M staging of gallbladder adenocarcinoma. The expression level of Ecadherin can be used as a biological indicator of prognosis of gallbladder carcinoma.