目的：研究白细胞介素６（ＩＬ６）及其可溶性受体（ｓＩＬ６Ｒα、ｓｇｐｌ３０）水平与乳腺癌的发生发展关系。方法：应用ＥＬＩＳＡ法测定４５例乳腺癌、１０例良性乳腺病ＩＬ６及其受体水平，并以１７例健康妇女为对照。结果：乳腺癌外周血ＩＬ６、可溶性受体（ｓＩＬ６Ｒα、ｓｇｐｌ３０）水平明显高于良性病组及正常对照组，且随病期进展而升高，与腋窝淋巴结转移呈正相关。结论：上述结果提示ＩＬ６、ｓＩＬ６Ｒα、ｓｇｐｌ３０可能是反映乳腺癌生物学行为及预后的重要指标 Objective: To study the relationship between the level of interleukin 6 (IL6) and its soluble receptors (sIL6Rα, sgpl30) and the occurrence and development of breast cancer. METHODS: The levels of IL6 and its receptors in 45 cases of breast cancer and 10 cases of benign breast disease were measured by ELISA and compared with 17 healthy women. Results: The levels of IL6, soluble receptors (sIL6Rα, sgpl30) in peripheral blood of breast cancer were significantly higher than those in benign disease group and normal control group. The levels of IL6 and soluble receptors (sIL6Rα, sgpl30) were positively correlated with axillary lymph node metastasis. Conclusion: These results suggest that IL6, sIL6Rα and sgpl30 may be important indicators reflecting biological behavior and prognosis of breast cancer.