持续感染人乳头状瘤病毒(HPV)是宫颈癌的主要原因,其中HPV-16和HPV-18是最常见的致癌病毒型别。2004年,美国Dartmouth医学院Harper等发现,抗这两型病毒的疫苗能预防宫颈癌,但其长期效果和安全性尚不清楚。Harper等对上述试验中的800名妇女进行了随访,她们均注射过3剂HPV-16/HPV Persistent human papillomavirus (HPV) is a major cause of cervical cancer, of which HPV-16 and HPV-18 are the most common oncogenic virus types. In 2004, Harper et al. At Dartmouth Medical School in the United States found that vaccines against these two types of viruses can prevent cervical cancer, but the long-term efficacy and safety of the vaccine are not yet clear. Harper et al. Followed up 800 women in the trial, who had received three doses of HPV-16 / HPV