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Purpose: An immunological reaction to a bacterial antigen, such as Mycobacteri umtuberculosis or Propionibacteriumspp., is suspected to be an initial mechanism in the disorder known as sarcoidosis. We investigated whether or not P. acnes, P. granulosum or M. tuberculosis are present in the vitreous fluid of eyes suffe ring from uveitis with sarcoidosis. Methods: Using polymerase chain reaction, we analysed the presence of P. acnes, P. granulosum and/or M. tuberculosis DNA in vitreous samples taken from six eyes with sarcoidosis and six control eyes. Resu lts: Among the six uveitis eyes with sarcoidosis, we detected P. acnes DNA in tw o eyes, P. granulosum DNA in four eyes, and both P. acnes and P. granulosum DNA in one eye, but no Propionibacterium spp. in the control eyes. M. tuberculosis D NA was not present in any of the patient or control eyes. Conclusions: This is t he first report indicating the presence of Propionibacterium spp. and/or its DNA in the vitreous fluid of sarcoidic eyes with uveitis. This, therefore, supports the idea that Propionibacterium spp. are involved in the aetiology of uveitis i n sarcoidosis.
Purpose: An immunological reaction to a bacterial antigen, such as Mycobacteri umtuberculosis or Propionibacterium spp., Is suspected to be an initial mechanism in the disorder known as sarcoidosis. We investigated whether or not P. acnes, P. granulosum or M. tuberculosis are present in the vitreous fluid of eyes suffe ring from uveitis with sarcoidosis. Methods: Using polymerase chain reaction, we analyzed the presence of P. acnes, P. granulosum and / or M. tuberculosis DNA in vitreous samples taken from six eyes with sarcoidosis and six control eyes. Resu lts: Among the six uveitis eyes with sarcoidosis, we detected P. acnes DNA in tw o eyes, P. granulosum DNA in four eyes, and both P. acnes and P. granulosum DNA in one eye, but no Propionibacterium spp. in the control eyes. M. tuberculosis D NA was not present in any of the patient or control eyes. Conclusions: This is he he first report indicating the presence of Propionibacterium spp. and / or its DNA in the vitreous fluid of sarcoidicThis, therefore, with the idea that Propionibacterium spp. are involved in the aetiology of uveitis i n sarcoidosis.