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目的:观察由儿童清肺丸经工艺和剂型改进研制后的口服液的药效学作用。方法:采用酵母菌致热法观察解热作用;小鼠耳肿胀实验、角叉菜胶致大鼠足趾肿胀及醋酸诱发小鼠腹腔毛细血管通透性实验观察其抗炎作用;采用体外液体微量稀释法进行呼吸道相关致病菌抑菌实验。结果:儿童清肺口服液可抑制酵母菌所致大鼠发热,明显抑制小鼠耳肿胀程度和大鼠足跖肿胀度,降低腹腔毛细血管通透性。儿童清肺口服液对金黄色葡萄球菌、绿脓杆菌、肺炎球菌、肺炎杆菌有抑制作用,抑制率均为100%,儿童清肺口服液的MIC50为40.86mg生药/m L。结论:儿童清肺口服液具有明显的解热、抗炎及抑菌作用。
OBJECTIVE: To observe the pharmacodynamic effects of oral liquid prepared by the improvement of process and dosage form of Qingqiong pill for children. Methods: The antipyretic effect was observed by yeast thermophilic method. The mouse ear swelling test, carrageenan induced rat toe swelling and acetic acid induced peritoneal capillary permeability in mice were used to observe the anti-inflammatory effects. Antibacterial activity of respiratory pathogens by micro - dilution method. Results: Qingfei oral liquid can inhibit the fever caused by yeast in rats, significantly inhibit the ear edema in mice and foot swelling in rats, reduce the peritoneal capillary permeability. Children Qingfei oral liquid Staphylococcus aureus, Pseudomonas aeruginosa, pneumococcus, Klebsiella pneumoniae inhibitory effect, the inhibition rate was 100%, children Qingfei oral MIC50 was 40.86mg crude drug / m L. Conclusion: Children Qingfei oral solution has obvious antipyretic, anti-inflammatory and antibacterial effects.