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目的:了解巯甲丙脯酸(Captopril)介入肾显像,对评价糖尿病患者肾脏血流和功能变化的临床价值。方法:对15例正常对照和46例血压正常的2型DM患者进行了基础肾显像(BRI)和巯甲丙脯酸介入肾显像(CRI),测量介入前后的肾小球滤过率(GFR)、峰时(Tp)、半排时间(T1/2)、20分残留率(C20)。结果:DM较对照组GFR增高,Tp、T1/2逐渐延长,C20增加。介入前后对照组的血压、GFR、Tp、T1/2、C20无明显改变。DM患者血压略下降,GFR均降低,DM1组Tp、T1/2缩短,C20降低。DM2组Tp缩短,T1/2、C20无明显变化。DM3组Tp、T1/2均延长,C20增高。结论:CRI可灵敏、准确地反映分肾功能和血流情况的变化,对DM的分期、判断疗效、指导治疗等有重要价值。
Objective: To investigate the clinical value of captopril-mediated renal imaging in assessing renal blood flow and functional changes in diabetic patients. Methods: Basic renal imaging (BRI) and captopril-mediated renal imaging (CRI) were performed in 15 normal controls and 46 normotensive patients with type 2 DM, and the glomerular filtration rate (GFR), peak time (Tp), half-row time (T1 / 2) and residual rate of 20 (C20). Results: Compared with the control group, GF increased GFR, Tp, T1 / 2 gradually extended, C20 increased. The blood pressure, GFR, Tp, T1 / 2 and C20 of the control group before and after intervention did not change significantly. DM patients slightly decreased blood pressure, GFR were reduced, DM1 group Tp, T1 / 2 shortened, C20 decreased. Tp in DM2 group was shortened, while there was no obvious change in T1 / 2 and C20. DM3 group Tp, T1 / 2 are extended, C20 increased. Conclusion: CRI can sensitively and accurately reflect the changes of renal function and blood flow, and has important value in staging, judging efficacy and guiding treatment of DM.