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有报告用安妥明治疗高脂蛋白血症,常伴发一时性转氨酶增高。用本药喂鼠,其肝脏超微结构、酶的活性、代谢物以及二磷酸腺甙/三磷酸腺甙比值发生改变,也有报告。Hanefeld等报告用安妥明治疗高脂蛋白血症患者,活检可见肝糖原、锰含量减少,而在线粒体、滑面内质网中则增加。作者等对40例高脂蛋白血症患者,给予本药治疗,并在治疗前/后3个月行肝活检。40例中27例的剂量为1.5g/日;13例为0.5g/日。结果27例(1.5g/日)治疗前脂变性Ⅰ度(微量到中等)者9例,Ⅱ度(明显)者17例,Ⅲ度(严重脂变)者0例,Ⅳ度(脂肝)者1例。治疗3个月后,2例无脂变性,Ⅰ
There are reports of treatment with clofibrate hyperlipoproteinemia, often accompanied by temporary transaminases increased. With the drug-fed mice, the liver ultrastructure, enzyme activity, metabolites and adenosine diphosphate / adenosine triphosphate ratio changes have also been reported. Hanefeld et al reported that patients with hyperlipoproteinemia were treated with clofibrate, liver glycogen was found biopsy, manganese content decreased, while in the mitochondria, slide the endoplasmic reticulum was increased. The author of 40 cases of hyperlipoproteinemia in patients given this drug treatment, and in the treatment of 3 months before / after liver biopsy. In 40 cases, the dose of 27 cases was 1.5g / day; 13 cases was 0.5g / day. Results Among the 27 cases (1.5g / day), there were 9 cases of grade Ⅰ (trace to moderate), 17 cases of grade Ⅱ (markedly), 0 case of grade Ⅲ (severe fat), grade Ⅳ In 1 case. Three months after treatment, two cases had no lipid degeneration, Ⅰ