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目的探讨鼠源性神经生长因子(mNGF)治疗对正己烷中毒患者内源性神经生长因子(NGF)水平的影响。方法 9例正己烷中毒患者(病例组)经mNGF治疗1、6及12个月后,分别检测血清内源性NGF水平,并与正常对照人群(对照组)比较。结果病例组3次检测血清内源性NGF水平均低于检出限值(30 ng/L),检出率为0%,对照组血清内源性NGF检出率为35.7%。mNGF治疗1年后,病例组周围神经异常表现均有显著改善。结论正己烷中毒患者血清内源性NGF水平较低;mNGF能显著改善患者的周围神经异常表现;血清内源性NGF水平恢复晚于神经行为异常的恢复,恢复到正常水平可能需要较长时间。
Objective To investigate the effect of murine nerve growth factor (mNGF) on the level of endogenous nerve growth factor (NGF) in n-hexane poisoning patients. Methods Nine patients with n-hexane poisoning (case group) were treated with mNGF for 1, 6, and 12 months. Serum levels of endogenous NGF were measured and compared with those of normal controls (control group). Results Serum levels of endogenous NGF were lower than the detection limit (30 ng / L) in 3 times of the test. The detection rate was 0%. The detection rate of endogenous NGF in the control group was 35.7%. After 1 year of mNGF treatment, the peripheral nerve abnormalities in the case group were significantly improved. CONCLUSIONS: N-hexane levels in patients with n-hexane poisoning are low. MNGF can significantly improve the performance of peripheral nerve abnormalities. Serum levels of endogenous NGF are restored later than those of neurological abnormalities. It may take a long time to recover to normal levels.