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目的探讨血浆中神经肽Y(neuropeptideY,NPY)、内皮素(endothelin,ET)及甲襞微循环在原发性高血压和有原发性高血压史的脑卒中的发病过程中的变化及临床意义。方法采用放射免疫法ra-dioimmunoassay分别测定原发性高血压、脑梗死、脑出血患者和正常对照组血浆中NPY、ET的含量及使用微循环测定仪观察以上各组甲襞微循环变化。结果原发性高血压、脑梗死、脑出血患者与正常对照组比较,血浆中NPY、ET的含量增高,微循环异常积分增高(P均<0.01),但患者各组之间比较差异均无显著性(P>0.05)。结论原发性高血压、脑卒中患者存在神经内分泌异常,血管内皮细胞受损及微循环障碍,这些改变可能参与了这两类疾病的发病过程。
Objective To investigate the changes of neuropeptide Y (NPY), endothelin (ET) and microcirculation in plasma during the pathogenesis of stroke with essential hypertension and essential hypertension significance. Methods Radioimmunoassay ra-dioimmunoassay was used to determine plasma NPY and ET contents in patients with essential hypertension, cerebral infarction, cerebral hemorrhage and normal control group respectively. The changes of formazan microcirculation in each group were observed by microcirculation analyzer. Results Compared with the normal control group, the plasma levels of NPY and ET were increased and the abnormal microcirculation scores were increased in patients with essential hypertension, cerebral infarction and cerebral hemorrhage (P <0.01), but no significant difference was found between the groups Significance (P> 0.05). Conclusion There are neuroendocrine disorders, impaired vascular endothelial cells and microcirculation in patients with essential hypertension and stroke. These changes may be involved in the pathogenesis of these two types of diseases.