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目的研究不同BMI人群的空腹血浆内毒素(LPS)水平,分析LPS影响因素及其与BMI、IR的关系。方法纳入99例受试者,根据OGTT结果分为NGT与T2DM组,以BMI=28 kg/m2为切点,再分为肥胖(OB)与非肥胖(non-OB)亚组,检测血浆LPS、血清高敏C反应蛋白(hsC-RP)等。采用简单相关分析LPS与BMI、HOMA-IR等指标相关性、采用多元线性回归分析LPS及HOMA-IR的影响因素。结果无论是NGT还是T2DM,其肥胖亚组人群的空腹血浆LPS较非肥胖亚组高2~3倍,予以诊断为代谢性内毒素血症状态;LPS水平与BMI(r=0.307)、HbA1 c(r=0.454)、hsC-RP(r=0.254)、ALT(r=0.881)、AST(r=0.848)、HOMA-IR(r=0.509)、FPG(r=0.450)相关(P<0.05);多元线性回归分析发现,BMI、HbA_1c是LPS的影响因素,BMI、LPS是HOMA-IR的影响因素。结论随着BMI的增加,血浆LPS水平逐渐升高,机体处于低度炎症、代谢性内毒素血症状态,可加重IR程度。
Objective To study the level of fasting plasma endotoxin (LPS) in different BMI population, analyze the influencing factors of LPS and its relationship with BMI and IR. Methods Ninety-nine subjects were enrolled and divided into NGT and T2DM groups according to OGTT results. BMI = 28 kg / m2 was used as the cut-off point and then divided into obese and non-obese subgroups. Plasma LPS , Serum high-sensitivity C-reactive protein (hsC-RP) and so on. Simple correlation analysis of LPS and BMI, HOMA-IR and other indicators of correlation, the use of multiple linear regression analysis of LPS and HOMA-IR factors. Results No matter NGT or T2DM, the fasting plasma LPS of obese subgroup was 2 ~ 3 times higher than that of non-obese subgroup, which was diagnosed as metabolic endotoxemia; LPS level was positively correlated with BMI (r = 0.307), HbA1c (r = 0.454), hsC-RP (r = 0.254), ALT (r = 0.881), AST (r = 0.848), HOMA-IR Multivariate linear regression analysis found that BMI and HbA_1c were the influencing factors of LPS, while BMI and LPS were the influencing factors of HOMA-IR. Conclusions With the increase of BMI, plasma LPS levels gradually increased, the body in a low degree of inflammation, metabolic endotoxemia, may increase the degree of IR.