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目的 :在既往关于白介素 1β受体阻断剂可部分反转利血平引起的大鼠的行为性抑郁研究的基础上 ,探讨腹腔注射利血平对脑内白介素 1β含量的影响。 方法 :采用Porsolt游泳实验 ,检测腹腔注射利血平 (2、6和 8mg kg)后大鼠的行为抑郁。ELISA法检测脑内白介素 1β的含量。 结果 :发现在腹腔注射利血平 1～ 72小时内 ,引起大鼠的行为性抑郁。大脑皮质、海马和下丘脑中白介素 1β的含量在利血平注射后 2 4小时开始升高 ,4 8小时达到高峰 ,其中以下丘脑为最明显。 结论 :利血平增加脑内白介素 1β的含量 ,可能是利血平引起的行为性抑郁的机制之一。
OBJECTIVE: To investigate the effect of intraperitoneal injection of reserpine on the content of interleukin-1β in brain based on the previous studies on behavioral depression in rats induced by partial reversal of reserpine by interleukin-1β receptor blocker. Methods: Porsolt swimming test was used to investigate behavioral depression in rats after intraperitoneal injection of reserpine (2, 6 and 8 mg kg). The content of interleukin-1β in the brain was detected by ELISA. Results: We found that intraperitoneal injection of reserpine within 1 to 72 hours, causing behavioral depression in rats. Interleukin-1β levels in cerebral cortex, hippocampus and hypothalamus began to increase 2-4 hours after reserpine injection, reaching the peak at 48 hours, of which the hypothalamus was the most obvious. Conclusion: Reserpine increased the level of interleukin-1β in the brain may be one of the mechanisms of reserpine-induced behavioral depression.