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目的观察米非司酮治疗子宫肌瘤的临床效果。方法确诊为子宫肌瘤患者54例均予米非司酮治疗,疗程为6个月,观察疗效及不良反应。结果 B型超声检查显示子宫及肌瘤的体积均显著变小,雌孕激素水平较治疗前显著下降;用药后少数病例出现轻微不适,未见严重不良症状。结论米非司酮用于子宫肌瘤的治疗,能显著减小肌瘤体积或抑制肌瘤变大,控制雌孕激素水平,治疗过程中不良反应少,疗效显著、安全。
Objective To observe the clinical effect of mifepristone in treating uterine fibroids. Methods 54 cases of uterine fibroids were treated with mifepristone, the course of treatment was 6 months, the efficacy and adverse reactions were observed. Results B-mode ultrasonography showed that the volume of uterus and fibroids decreased significantly, and the level of estrogen and progesterone decreased significantly compared with that before treatment. There was a slight discomfort in a few cases after treatment, and no serious adverse symptoms were found. Conclusion The use of mifepristone in the treatment of uterine fibroids can significantly reduce the size of fibroids or inhibit fibroids enlargement, and control the levels of estrogen, progesterone and progesterone. There are few adverse reactions in the course of treatment. The curative effect is significant and safe.