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目的探讨血清AFP、GP73、GPC3及TSGF的联合检测在原发性肝癌诊断中的应用价值。方法选取2015年1月-2016年1月我院收治的52例原发性肝癌患者、慢性乙型肝炎患者(CHB)60例、肝硬化患者(LC)66例作为研究对象,对照组为同期的健康体检者50例。比较四组AFP、GP73、GPC3、TSGF水平及诊断效能。结果 PHC组、CHB组、LC组患者的AFP、GP73、GPC3及TSGF水平均显著高于正常组,差异有统计学意义(P<0.05)。经过组间比较,PHC组患者的AFP、GP73、GPC3及TSGF水平均显著高于CHB组和LC组患者,差异有统计学意义(P<0.05)。血清AFP、GP73、GPC3及TSGF四项指标联合检测敏感度、特异度及准确度(96.0%、96.3%、96.2%)均显著高于任一单项指标检测结果,差异有统计学意义(P<0.05)。结论血清AFP、GP73、GPC3及TSGF对于原发性肝癌是敏感性指标,四者的联合检测能有效提高对原发性肝癌的诊断效能。
Objective To investigate the value of combined detection of serum AFP, GP73, GPC3 and TSGF in the diagnosis of primary liver cancer. Methods 52 patients with primary liver cancer, 60 patients with chronic hepatitis B (CHB) and 66 patients with cirrhosis (LC) were enrolled in our hospital from January 2015 to January 2016. The patients in control group were treated with the same period 50 cases of healthy people. Four groups of AFP, GP73, GPC3, TSGF levels and diagnostic efficacy were compared. Results The levels of AFP, GP73, GPC3 and TSGF in PHC group, CHB group and LC group were significantly higher than those in normal group (P <0.05). After comparing between groups, the levels of AFP, GP73, GPC3 and TSGF in PHC group were significantly higher than those in CHB group and LC group (P <0.05). The sensitivity, specificity and accuracy (96.0%, 96.3%, 96.2%) of the combined detection of serum AFP, GP73, GPC3 and TSGF were significantly higher than those of any single index (P < 0.05). Conclusion Serum AFP, GP73, GPC3 and TSGF are indicators of sensitivity to primary liver cancer. The combination of the four tests can effectively improve the diagnostic efficacy of primary liver cancer.