论文部分内容阅读
目的探讨小剂量克拉霉素治疗内镜鼻窦手术后鼻窦炎持续症状的疗效及其治疗时限。方法48例成人慢性鼻窦炎ESS术后持续鼻窦炎症状的病人随机分为3组,A组18人服药周期3个月,B组16人服药周期6个月,C组14人服药周期12个月,全部病例应用小剂量克拉霉素(250mg次,1次/d,口服)治疗,治疗结束后继续观察随访6个月以上,分别在治疗开始前、治疗结束后根据症状、体征、及影像学检查分值进行统计学分析。结果A组治疗前后比较,有统计学意义(P<0.05),B、C组治疗前后比较差异有统计学意义(P<0.01);A、C组治疗后总体疗效比较差异有统计学意义(P<0.01),B、C组治疗后总体疗效比较差异无统计学意义(P>0.05)。结论应用小剂量克拉霉素是治疗内镜鼻窦手术后持续鼻窦炎症状的有效方法,服药时限以6个月为宜。
Objective To investigate the curative effect and duration of continuous treatment of sinusitis after endoscopic sinus surgery with low-dose clarithromycin. Methods 48 patients with chronic sinusitis and sinusitis after ESS patients were randomly divided into 3 groups, 18 patients in group A took 3 months, 16 patients in group B took 6 months, 14 patients in group C took 12 drugs Month, all cases of low-dose clarithromycin (250mg times, 1 / d, oral) treatment, after the end of treatment continued to observe the follow-up of more than 6 months, respectively, before the start of treatment, after treatment based on symptoms, signs, and images School check scores for statistical analysis. Results A group before and after treatment was statistically significant (P <0.05), B, C group before and after treatment was significantly different (P <0.01); A, C group after treatment the overall effect was statistically significant difference P <0.01). There was no significant difference in overall curative effect between B and C groups after treatment (P> 0.05). Conclusion The application of low-dose clarithromycin is an effective method to treat the symptoms of sinusitis after endoscopic sinus surgery. The time limit of taking clarithromycin should be 6 months.