孤独症谱系障碍(autism spectrum disorder,ASD)是一类神经发育障碍,发病率逐渐增高而病因至今未明,可能与遗传和环境因素的相互作用有关。妊娠期母体营养状况是重要的环境因素之一。近年来母体维生素代谢异常与ASD发病之间的关系受到重视。本文将从遗传、蛋白修饰和免疫调节等方面综述母体维生素代谢水平与子代ASD发病之间的关系。 Autism spectrum disorder (autism spectrum disorder, ASD) is a kind of neurodevelopmental disorder, the incidence is gradually increased and the etiology is unknown so far, which may be related to the interaction of genetic and environmental factors. Maternal nutrition status during pregnancy is one of the important environmental factors. In recent years, maternal vitamin metabolic abnormalities and the relationship between the incidence of ASD attention. This article reviews the relationship between maternal vitamin metabolism and offspring onset of ASD in terms of inheritance, protein modification and immunomodulation.