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香肉果Casinuiroa edulis Llave et Lex是产于墨西哥的树木,当地用作催眠和降压药。本文报导了其种子的水提取物对麻醉狗的心血管药理作用。种子经环己烷脱脂,干燥,核仁粉末分别用1:1甲醇-乙醇混合液及水提取,水提取液经真空干燥后溶于等渗氯化钠溶液中供药理实验用。第一个试验中,动物分为直接静注提取物(10mg/kg)组和用H_1拮抗剂盐酸苯海拉明(10mg/kg)、H_2阻断剂甲氰脒胍(3.1mg/kg)组及两药合用预先静注处理10min后再
Muscats Cacinuiroa edulis Llave et Lex is a tree grown in Mexico and used locally as a hypnotic and antihypertensive agent. This article reports on the cardiovascular pharmacological effects of its seed water extract on anesthetized dogs. The seeds were defatted with cyclohexane and dried. The nucleolus powder was extracted with 1:1 methanol-ethanol mixture and water, respectively. The water extract was dried in vacuum and then dissolved in isotonic sodium chloride solution for pharmacological experiments. In the first trial, animals were divided into the direct intravenous injection (10 mg/kg) group and the H_1 antagonist diphenhydramine hydrochloride (10 mg/kg) and the H_2 blocker dicyandiamide (3.1 mg/kg). The group and the two drugs are combined beforehand for 10 min