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雄性鹌鹑用高脂饲料喂养8wk能形成典型的高脂血症和动脉粥样硬化斑块,给动物po硫酸苷糖酯(PGMS)50及25 mg·kg~1·d~1,能明显抑制鹌鹑血清总胆固醇TC及(LDL+VLDL)C水平的升高,提高HDL C/TC及HDL_2/HDL_3 C比值,实验8 wk末,高脂组动脉病变重,斑块发生率为91.7％(11/12);PGMS高,低剂量组动脉病变轻,斑块发生率分别为25.0％(3/12)及41.7％(5/12).光镜和电镜观察表明,用药组动脉内膜增生明显轻于高脂组,提示硫酸甘糖酯对平滑肌细胞的增生具有抑制作用,并能延缓动脉粥样硬化的发生和发展。
Male piglets fed with high-fat diet for 8 weeks can develop typical hyperlipidemia and atherosclerotic plaques, giving animals PGMS 50 and 25 mg·kg~1·d~1, which can significantly inhibit The serum levels of total cholesterol TC and (LDL+VLDL)C increased and increased HDL C/TC and HDL 2/HDL 3 C ratios. At the end of the 8th week of experiment, the high-fat group had severe arterial disease and the plaque incidence was 91.7% (11 / 12); PGMS high and low dose group arterial lesions were light, plaque incidence were 25.0% (3/12) and 41.7% (5/12). Light and electron microscopy showed that the intimal hyperplasia of the drug group was significantly Lighter than the high-fat group, it was suggested that the Glycosyl Sulfate has an inhibitory effect on the proliferation of smooth muscle cells, and can delay the occurrence and development of atherosclerosis.