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目的观察小承气汤加减联合西医常规治疗重型颅脑损伤术后肺部感染的临床疗效。方法将67例重型颅脑损伤术后肺部感染患者随机分为治疗组(34例)和对照组(33例)。两组均给予西医常规治疗,治疗组加服小承气汤加减。两组疗程均为7天,观察临床疗效,比较相关生化指标,包括白细胞计数(WBC)、超敏C反应蛋白(CRP)、降钙素原(PCT)以及临床肺部感染评分(CPIS评分)的变化情况。结果①治疗组、对照组临床总有效率分别为93.33%和70.00%;组间临床疗效比较,差异有统计学意义,治疗组优于对照组(P<0.05)。②组间治疗3天后比较,PCT水平差异有统计学意义(P<0.05);组间治疗7天后比较,WBC、CRP、PCT及CPIS评分水平差异有统计学意义(P<0.05)。结论小承气汤加减联合西医常规治疗重型颅脑损伤术后肺部感染,疗效满意,可显著减轻肺部感染及炎症反应。
Objective To observe the clinical effect of Xiaochengqi Decoction combined with Western routine treatment of pulmonary infection after severe craniocerebral injury. Methods Sixty-seven patients with severe head injury after lung infection were randomly divided into treatment group (34 cases) and control group (33 cases). Both groups were given routine treatment of Western medicine, the treatment group plus Xiao Cheng Qi Decoction. The course of treatment was 7 days in both groups. The clinical curative effect was observed. The related biochemical indexes such as WBC, CRP, PCT and CPIS score were compared. Changes in the situation. Results ① The total clinical effective rates of the treatment group and the control group were 93.33% and 70.00%, respectively. There was significant difference between the two groups in clinical curative effect. The treatment group was superior to the control group (P <0.05). There were significant differences in PCT levels between the two groups after 3 days of treatment (P <0.05). There were significant differences in WBC, CRP, PCT and CPIS score between the two groups after treatment for 7 days (P <0.05). Conclusions Xiaochengqi Decoction combined with western medicine routine treatment of pulmonary infection after severe craniocerebral injury, with satisfactory results, can significantly reduce lung infection and inflammatory response.