论文部分内容阅读
目的探讨中性粒细胞计数与非酒精性脂肪肝(NAFLD)的关联性。方法基于大规模健康管理队列,针对队列基线中无NAFLD的15 463例健康体检对象随访,平均随访时间2.54年,随访结局为发生NAFLD;将基线中性粒细胞计数根据四分位数由低到高划分为4个组段(Q1、Q2、Q3、Q4);采用多元Cox回归计算中性粒细胞计数与NAFLD关联性的相对危险度(HR)。结果随访期间3 846人被诊断为NAFLD。Cox结果显示,以Q1为参照,在调整年龄、性别后,中性粒细胞计数的Q2、Q3、Q4三个组段的HR(95%CI)分别为1.265(1.057,1.514)、1.446(1.214,1.724)、1.605(1.350,1.907),上述基础上再调整谷丙转氨酶和γ-谷酰胺转酞酶后,Q2、Q3、Q4三个组段的HR(95%CI)分别为1.264(1.056,1.512)、1.434(1.202,1.710)、1.582(1.330,1.882),进一步调整血脂四项、空腹血糖、体质量指数(BMI)和高血压后,HR(95%CI)分别为1.181(0.986,1.415)、1.189(0.995,1.420)、1.226(1.026,1.464)。结论中性粒细胞计数是NAFLD发病的独立危险因素。
Objective To investigate the association between neutrophil count and non-alcoholic fatty liver disease (NAFLD). Methods Based on a large-scale health management cohort, 15 463 healthy subjects without NAFLD at baseline were followed up for an average follow-up of 2.54 years. The follow-up outcome was NAFLD. Baseline neutrophil count was calculated from quartile to Highly divided into 4 groups (Q1, Q2, Q3, Q4); relative risk (HR) was calculated using multivariate Cox regression to correlate neutrophil count with NAFLD. Results 3 846 people were diagnosed with NAFLD during follow-up. Cox results showed that the HR (95% CI) of the three groups of Q2, Q3 and Q4 were 1.265 (1.057 and 1.514) and 1.446 (1.214 , 1.724) and 1.605 (1.350, 1.907) respectively. HR and 95% CI of Q2, Q3 and Q4 were 1.264 and 1.056 respectively after adjustment of alanine aminotransferase and γ- , 1.512), 1.434 (1.202,1.710) and 1.582 (1.330,1.882), HR (95% CI) were 1.181 (0.986, 1.415), 1.189 (0.995, 1.420), 1.226 (1.026, 1.464). Conclusion Neutrophil count is an independent risk factor for the pathogenesis of NAFLD.