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p75神经营养因子受体属于神经营养因子的受体之一。越来越多的研究表明,p75NTR在心血管系统自主神经中发挥重要的作用,不仅促进交感神经的生长发育,还调节心脏神经递质的释放。p75NTR还抑制新生血管形成,具有一定的抗血管生成作用,且介导平滑肌细胞凋亡,加重血管粥样硬化损伤。p75NTR这些特性表明其抑制剂存在重要的治疗潜能,或许能够改善缺血所致的损伤,如冠心病、急性心肌梗死、周围血管病变等。
The p75 neurotrophin receptor is one of the receptors for neurotrophic factors. More and more studies have shown that p75NTR plays an important role in cardiovascular autonomic nervous system, which not only promotes the growth and development of sympathetic nerves, but also regulates the release of cardiac neurotransmitter. p75NTR also inhibits neovascularization, has a certain anti-angiogenic effect, and mediates smooth muscle cell apoptosis, aggravating vascular atherosclerosis. p75NTR These properties indicate that there is an important therapeutic potential for their inhibitors and may improve ischemic damage such as coronary heart disease, acute myocardial infarction, and peripheral vascular disease.