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氯苯胍(白乐君)问世后,许多学者研究它的抗瘧作用,发现其在体外对瘧原虫并无作用;若与切碎的肝臟共同存在时,即能杀灭瘧原虫。因此断定氯苯胍与肝臟共同存在时,产生一种代謝物,通过这种代謝物,才对瘧原虫显示作用。经Brackett,Woletsky(1946);Curd,Landquist,Rose(1947);Cuthbertson和Moffatt(1948)諸氏的观察,认为这种代謝物对鷄瘧原虫确有抑制作用。1953年又经Carrington, Crowther与Levi諸氏进一步的研究,从曾服氯苯胍的兔子小便中分离出一种效用很高的代謝物,它对鷄瘧原虫有强大杀灭作用。经试验证明,其效力较氯苯胍大10倍,并且阐明了这种代謝物即为三嗪(Triazine)化合物的一种,化学
After the advent of chlorpromazine (Bai Lejun), many scholars study its anti-malarial effect and found that it has no effect on the parasite in vitro; if it is co-existing with the shredded liver, it can kill the parasite. Therefore, the co-existence of chlorpromazine with the liver produced a metabolite that showed no effect on the parasite. Observations by Brackett, Woletsky (1946); Curd, Landquist, Rose (1947); Cuthbertson and Moffatt (1948) suggest that this metabolite does have an inhibitory effect on Plasmodium malariae. Further studies by Carrington, Crowther and Levi in 1953 led to the isolation of a highly potent metabolite from the urine of rabbits who had been given progluconazole, a powerful killer of Plasmodium malariae. It has been proved by experiments that it is 10 times more effective than chlorpromazine and it is elucidated that this metabolite is a kind of triazine compound,