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目的探讨p53 Arg72Pro多态性与新疆维吾尔族宫颈癌发生的相关性。方法采用PCR-RFLP和PCR方法检测152例维吾尔族宫颈癌组织和110例维吾尔族正常宫颈组织中p53Arg/Arg、Pro/Pro、Arg/Pro3种基因型的分布和HPV16DNA。结果p53基因型Arg/Arg、Pro/Pro、Arg/Pro在维吾尔族宫颈癌中的分布频率为46.0%、13.2%、40.8%,对照组为30.0%、14.5%、55.5%,两组总构成比差异有统计学意义(χ2=7.196,P<0.05),Arg/Arg在宫颈癌中所占比例高于其它两个基因型,且高于对照组中Arg/Arg的比例。维族宫颈癌患者HPV16阳性率为74.3%。在维族宫颈癌组中,HPV16阳性组p53基因型Arg/Arg、Pro/Pro、Arg/Pro的分布频率为48.7%、8.8%、42.5%,HPV16阴性组为38.5%、25.6%、35.9%,两组总构成比差异有统计学意义(χ2=7.177,P<0.05)。结论p53 Arg72Pro多态性可能与新疆维吾尔族宫颈癌发生相关,p53 Arg/Arg基因型可能是新疆维吾尔族宫颈癌发生的遗传易感因素,且与维吾尔族HPV相关宫颈癌的发生有关。
Objective To investigate the relationship between p53 Arg72Pro polymorphism and the occurrence of Uygur cervical cancer in Xinjiang. Methods The genotypes of p53Arg / Arg, Pro / Pro and Arg / Pro in 152 cases of Uigur cervical cancer and 110 cases of Uygur normal cervix were detected by PCR-RFLP and PCR. Results The frequency of Arg / Arg, Pro / Pro and Arg / Pro in the Uygur cervical cancer was 46.0%, 13.2% and 40.8%, respectively, while the control group was 30.0%, 14.5% and 55.5% (Χ2 = 7.196, P <0.05). The proportion of Arg / Arg in cervical cancer was higher than that in the other two genotypes, which was higher than that of control group. Uighur cervical cancer patients HPV16 positive rate was 74.3%. The frequency of Arg / Arg, Pro / Pro, Arg / Pro in HPV16 positive group was 48.7%, 8.8%, 42.5% in HPV16 positive group and 38.5%, 25.6%, 35.9% in HPV16 negative group, There was significant difference between the two groups (χ2 = 7.177, P <0.05). Conclusion The polymorphism of p53 Arg72Pro may be related to the occurrence of Uygur cervical cancer in Xinjiang. The genotype of p53 Arg / Arg may be the genetic predisposing factor for Uigur cervical cancer in Xinjiang and is related to the occurrence of HPV-related cervical cancer in Uygur.