氨巯基类抗放药的缺点之一是有效时间短,因此早就有人企图通过将短效抗放药潜伏在含有乙烯吡咯烷酮的聚合物中,以延长药物的有效时间,并降低其毒性。我们曾重复Ringsdorf报道的含四氢噻唑环的共聚物(Ⅱa),证明其在照前192小时内的几个时间点给大鼠静脉注射,都具有较好的辐射防护效果,然而未作进一步探讨。后来鉴于硫辛酸及其二乙胺基乙酯的抗放效果与它们的 One of the shortcomings of aminothiol anti-drug agents is their short effective time. Therefore, an attempt was made to prolong the drug’s expiration time and reduce its toxicity by lurking a short-acting anti-drug drug in a polymer containing vinylpyrrolidone. We repeated the tetrahydro-thiazole ring-containing copolymer (IIa) reported by Ringsdorf and demonstrated that intravenous injection of the compound to rats at various time points within 192 hours prior to irradiation gave better radioprotective effects, however, without further Discussion. Later in view of the anti-lethal effect of lipoic acid and its diethylaminoethyl ester with them