p53基因突变和功能丧失是人类恶性肿瘤中的重要基因变化。本研究试图通过检测卵巢肿瘤p53基因的突变和表达情况，并分析p53蛋白过度表达与临床预后因素的关系，探讨肿瘤抑制基因在卵巢恶性肿瘤发生和发展过程中所起的作用及临床价值。1资料与方法卵巢肿瘤共123例，其中良性上皮 Mutations and loss of p53 gene are important genetic alterations in human malignancies. This study attempts to detect the mutation and expression of p53 gene in ovarian tumors and analyze the relationship between p53 protein overexpression and clinical prognostic factors to explore the role and clinical value of tumor suppressor genes in the occurrence and development of ovarian cancer. 1 Materials and Methods A total of 123 cases of ovarian tumors, including benign epithelium