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多肽是由氨基酸通过肽键相连而成的一类化学活性物质。生物体内已发现的多肽种类达数万种,具有一定生理活性。多肽作为神经-内分泌系统调控的信号分子,在肥胖及相关并发症中的作用得到广泛揭示,如神经肽Y、脑肠肽、胰高血糖素样肽等。近年,多肽组学的快速发展给多肽研究再添新概念,其中非编码基因短开放阅读框编码、功能肽同源区域、大蛋白分子断裂片段等来源的多肽以及脂肪细胞自身产生的内源性多肽也开始引起研究者的重视。本文就多肽在肥胖中的研究进展和趋势展开综述,为肥胖的预防和治疗提供了新的靶点。
Polypeptides are a class of chemically active substances linked by amino acids through peptide bonds. Tissues have been found in organisms up to tens of thousands of species, with some physiological activity. Peptides, as signal molecules regulated by neuroendocrine system, have been widely revealed in the pathogenesis of obesity and related complications such as neuropeptide Y, ghrelin, glucagon-like peptide and so on. In recent years, the rapid development of peptideomology has added new concepts to polypeptide research. Among them, the non-coding short open reading frame coding, functional peptide homologous regions, peptides from large protein molecular fragment and other endogenous sources produced by adipocytes Polypeptides have also begun to attract researchers attention. This article reviews the research progress and trend of peptides in obesity, which provides a new target for the prevention and treatment of obesity.