染色体异常在习惯性流产的病因中占重要地位,其发生可能与染色体不稳定性增加有关。因此,作者研究了习惯性流产夫妇染色体脆性部位(常见型或结构性脆性部位,constitutive fragile sites,C-fra;罕见型脆性部位,rare fragile sites,R-fra),以了解其与染色体畸变的关系。 1 资料与方法 1.1 对象 1989年12月至1990年10月,随机选择北京妇产医院习惯性流产夫妇10对,平均年龄27岁, Chromosomal abnormalities in the cause of habitual abortion occupy an important position, its occurrence may be related to increased chromosome instability. Therefore, the authors studied chromosomal fragility sites (constitutive fragile sites, C-fra; rare fragile sites, R-fra) of habitual abortion couples to understand their association with chromosomal aberrations relationship. 1 Materials and Methods 1.1 Subjects December 1989 to October 1990, a random selection of Beijing Maternity Hospital, 10 pairs of habitual abortion couples, mean age 27 years,