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对１００例汉族正常无血缘关系的个体和按ＷＨＯ糖尿病诊断标准确诊的５４名汉族胰岛素依赖型糖尿病（ＩＤＤＭ）患者，采用非放射性同位素地高辛标记的ＤＲ_３基因碱基序列特异性寡核苷酸探针（ＤＲＢ１０３０１，０３０２），进行斑点杂交（Ｄｏｔ，ｂｌｏｔ）。结果显示正常对照组ＤＲ_３基因（ＤＲＢ１０３０１）携带者为６％，而ＩＤＤＭ病人高达５３．６％（Ｐ＜０．００１，ＲＲ＝１８．１７）。
A total of 100 Chinese Han unrelated unrelated individuals and 54 Han patients diagnosed with idiopathic diabetes mellitus (IDDM) diagnosed according to the WHO diagnostic criteria for diabetes were enrolled in this study. Non-radioisotope digoxigenin-labeled DR_3 gene sequence-specific oligonucleotides Probe (DRB10301, 0302) for Dot blotting. The results showed that DR_10 gene (DRB10301) carrier was 6% in normal control group and 53.6% in IDDM patients (P <0.001, RR = 18.17).