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给高热疟疾组患儿肌肉注射常规剂量氯喹后,引起突然死亡的例子在非洲各地屡有发生。为了了解发热对氯喹毒性的影响,以探索这些病例的死亡原因,并阐明注射氯喹前采用物理降温或给予退热剂的临床意义,作者在清醒和麻醉家兔身上比较了正常和人工致热情况下的各项指标,包括静脉注射致死剂量、心电Ⅱ导程、呼吸和血压变化等方面。致热器用Megathem Junior热电偶仪,它可使家兔升温华氏4度。清醒动物上的注入速度为每分钟1毫克/公斤,麻醉动物为0.63毫克/公斤。
Examples of sudden deaths caused by intramuscular injections of routine doses of chloroquine to children with hyperthermia have frequently occurred throughout Africa. To understand the impact of fever on the toxicity of chloroquine in order to explore the causes of death in these cases and to elucidate the clinical implications of physical cooling or the administration of antipyretics prior to the injection of chloroquine, the authors compared normal and artificial fever in awake and anesthetized rabbits Under the indicators, including intravenous lethal dose, ECG lead, breathing and blood pressure changes and so on. The Megathem Junior thermocouple was used as a heat generator to heat rabbits to 4 degrees Fahrenheit. The awake animals were infused at a rate of 1 mg / kg per minute and anesthetized animals at 0.63 mg / kg.